Animal-Free Recombinant Human TGF-Beta 1(Discontinued)

Product code: 32-20532

Reactivity : Human, Mouse

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For estimated delivery dates, please contact us at [email protected]


Amount : 10 µg
Purification : Purity:>= 98% by SDS-PAGE gel and HPLC analyses.
Content : This recombinant protein is supplied in lyophilized form.  
AA sequence : ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS
Alternative Name : Transforming Growth Factor-Beta 1, Differentiation inhibiting factor, Cartilage-inducing factor
Source:CHO cells
The three mammalian isoforms of TGF-Beta , TGF-Beta 1, Beta 2, and Beta 3, signal through the same receptor and elicit similar biological responses.  They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility, as well as synthesis and deposition of the extracellular matrix.  They are involved in various physiological processes, including embryogenesis, tissue remodeling and wound healing.  They are secreted predominantly as latent complexes, which are stored at the cell surface and in the extracellular matrix.  The release of the biologically active TGF-Beta isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1.  TGF-b1 is the most abundant isoform secreted by almost every cell type.  It was originally identified for its ability to induce phenotypic transformation of fibroblasts, and recently it has been implicated in the formation of skin tumors.  Recombinant Human TGF-Beta 1 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.

Determined by TGF-Beta 1’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells.  The expected ED50 is <=0.05 ng/ml, corresponding to a specific activity of>= 2 x 107 units/mg.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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