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Animal-Free Recombinant Human IL-22(Discontinued)

Product code: 32-20382

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Amount : 10 µg
Purification : Purity:>= 98% by SDS-PAGE gel and HPLC analyses.
Content : This recombinant protein is supplied in lyophilized form.  
AA sequence : MAPISSHCRL DKSNFQQPYI TNRTFMLAKE ASLADNNTDV RLIGEKLFHG VSMSERCYLM KQVLNFTLEE VLFPQSDRFQ PYMQEVVPFL ARLSNRLSTC HIEGDDLHIQ RNVQKLKDTV KKLGESGEIK AIGELDLLFM SLRNACI
Alternative Name : Interleukin-22, IL-TIF, Cytokine ZCYTO18

Source:E.coli
IL-22 is a member of the IL-10 family of regulatory cytokines, which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26.  Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions.  Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas.  IL-22 signals through a receptor system consisting of IL-10RBeta /CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family.  Recombinant Human IL-22 is a 33.6 kDa, non-disulfide-linked, homodimeric protein consisting of two 147 amino acid polypeptide chains.

Measured by its ability to induce IL-10 secretion in COLO 205 (human colon carcinoma cells).  The expected ED50for this effect is 0.7- 1.0 ng/ml.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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