Animal-Free Recombinant Human BD-5(Discontinued)

Product code: 32-20032

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Amount : 20 µg
Purification : Purity: >= 98% by SDS-PAGE gel and HPLC analyses.
AA sequence : GLDFSQPFPS GEFAVCESCK LGRGKCRKEC LENEKPDGNC RLNFLCCRQR I
Alternative Name : BD5, DEFB5, DEFB105a, Beta-Defensin 5

Source: E.coli
Defensins (Alpha and Beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system.  The Alpha-defensins are distinguished from the Beta-defensins by the pairing of their three disulfide bonds.  To date, six human Beta-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6.  Beta-defensins are expressed on some leukocytes and at epithelial surfaces.  In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells.  The Beta-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence.  Beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds.  Recombinant Human BD-5 is a 5.8 kDa protein containing 51 amino acid residues.

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