2019-nCoV Nucleocapsid Protein
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| Amount : | 1mg |
| Purification : | Greater than 95% as determined by reducing SDS-PAGE. |
| Content : | Supplied as a 0.2 µM filtered solution of 20 mM Tris-HCl, 300 mM NaCl, 10 % glycerol, 1mM EDTA, pH 8.0. |
| Storage condition : | Reconstituted protein solution should be stored at <-20°C. |
| AA sequence : | Expression Region: Recombinant 2019-nCoV Nucleocapsid Protein is produced by our E.coli expression system and the target gene encoding Met1-Ala419 is expressed with a 6His tag at the N-terminus. |
| Uniprot ID : | QHD43423.2 |
| Alternative Name : | 2019-nCoV coronavirus NP Protein; 2019-nCoV np Protein; 2019-nCoV novel coronavirus Nucleoprotein Protein. |
Source : E.coli ; Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is a most abundant protein of coronavirus. N protein packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.
Calculated MW: 49.4kDa
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
Ciszewski WM, Wozniak LA, Sobierajska K.
SARS-CoV-2 S and N protein peptides drive invasion abilities of colon cancer cells through TGF-B1 regulation.
Biochim Biophys Acta Mol Cell Res. 2023 Oct;1870(7):119541. doi: 10.1016/j.bbamcr.2023.119541. Epub 2023 Jul 17.
PMID: 37468071.
Ciszewski, W.M., Wo?niak, L.A. & Sobierajska, K.
Diverse roles of SARS-CoV-2 Spike and Nucleocapsid proteins in EndMT stimulation through the TGF-?-MRTF axis inhibited by aspirin.
Cell Commun Signal 22, 296 (2024).
https://doi.org/10.1186/s12964-024-01665-z
https://link.springer.com/article/10.1186/s12964-024-01665-z
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