Polyclonal Antibody to APG16L
Fig-1: Western blot analysis of APG16L. Anti-APG16L antibody (11-10020) was used at 4 µg/ml on Spleen lysate.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Rabbit IgG |
| Purification : | Protein A Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
ATG16L1/APG16L is part of a large protein complex that functions as a molecular scaffold mediating protein-protein interactions necessary for formation of the autophagosome in response to both classical and pathogen-related autophagy stimuli. APG16L protein contains an N-terminal Atg5-binding domain, a coiled-coil domain and a C-terminal WD (tryptophan-aspartic acid)-repeat domain. APG16L forms a complex with the Atg12 Atg5 conjugate and together they are actively translocated to the phagophore and are further elongated during autophagosome formation. Genetic variation in the APG16L gene has been recently implicated in Crohn's disease pathogenesis. Polymorphism within APG16L gene results in excessive production of IL-1beta and IL-6 culmunating in the inflammatory process in Crohn's disease.
Western blot analysis: 2-4 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm, Preautophagosomal structure membrane |
| Post transnational modification: | Phosphorylation at Ser-139 promotes association with the ATG12-ATG5 conjugate to form the ATG12-ATG5-ATG16L1 complex. |
| BioGrid: | 120375. 51 interactions. |
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